Publications

[30] Caprolactone-Functional Thermoresponsive Polymers via Direct Polymerization and Post-Polymerization Oxidation

M. Behzad Khoshgoee, G. Pardo, J. Knappenberger, K. Raheja, S. Tatton, M. K. Debnath, M. Karayilan,* 2026, under review.

[29] Dense Polymer Brush Growth from Gold Nanorod Surfaces Enabled by a Lipoic Acid-Derived RAFT Agent

N. Nupnar, M. Kumar Debnath, A. E. Hovorka, Md M. Alam, J. Yang, A. C. S. Samia, K. A. Streletzky, M. Karayilan,* M. J. A. Hore,* 2026, under revision.

[28] Grafting Density Controls Dextran Diffusion and Exclusion at Polymer Grafted Interfaces

D. Gagnon, A. Shorin, K. Raheja, S. Suresh, M. J. A. Hore, M. Karayilan, S. Morozova,* 2026, under revision.

[27] Predictive Framework for Degradation-Aware Plastic Classification Using Spectroscopy and Machine Learning for Proper Recycling

D. Basgeet, J. Hasan, K. Raheja, D. Mathur, S. Kuppannagari,* M. Karayilan,* MRS Commun., 2026.

https://doi.org/10.1557/s43579-026-01038-2

ChemRxiv Preprint: https://doi.org/10.26434/chemrxiv.15004007/v

Degradation-Aware Plastic Sorting Using Spectroscopy, Barcode Additives, and Deep Learning

[26] Injectable Ultrahigh Molecular Weight Fluorescent Copolymers for Bioimaging and Surgical Guidance

Y. Yuan, S. Beilharz, A. N. Hostetler, H. R. Everson, E. Srivastava, L. Young, N. Nupnar, O. B. Giebelhaus, M. J. A. Hore, F. H. Örge, D. Mathur, M. Karayilan,* Biomacromolecules, 2026, accepted.

ChemRxiv Preprint: https://doi.org/10.26434/chemrxiv.15004745/v1

[25] Automation-Guided RAFT Copolymerization via Semi-Batch Process for Sequence Control

Y. Yuan, A. Hostetler, J. Cui, N. Nupnar, O. B. Giebelhaus, M. J. A. Hore, M. Karayilan,* MRS Commun., 2026.

https://doi.org/10.1557/s43579-026-01026-6

2026 Early Career Materials Researcher Issue

ChemRxiv Preprint: https://doi.org/10.26434/chemrxiv.15004011/v1

[24] Thermoresponsive Fluorescent Polymers: Influence of Size, Composition, and Architecture

K. Raheja, S. Beilharz, A. Lalam, Md B. Hasan, D. Mathur, M. Karayilan,* Poly. Chem., 2026, 17, 3161-3174.

https://doi.org/10.1039/d6py00425c

ChemRxiv Preprint: https://doi.org/10.26434/chemrxiv-2025-btj2g

Polymer Chemistry Emerging Investigators Series

[23] Cultivating Safety Culture through Peer-Led Safety Minute Slides and Videos in Chemistry Research Environments

G. Pardo,# A. Patel,# K. Raheja, M. Behzad Khoshgoee, Md B. Hasan, A. N. Hostetler, Y. Yuan, M. Karayilan,* J. Chem. Educ., 2026, 103 (6): 3130–3137.

https://doi.org/10.1021/acs.jchemed.5c01836

ChemRxiv Preprint DOI: 10.26434/chemrxiv-2026-v29xk

[22] Multi-Responsive Polymers with Degradable Side-Chain Functionality for Controlled Hydrolysis

and Tunable Thermal Transition

M. Behzad Khoshgoee,# M. K. Debnath,# G. Pardo, Y. Yuan, M. Zeeshan, E. Mao, T. Gray, B. Gurkan, M. J. Bertin, M. Karayilan,*

RSC Appl. Polym., 2026, 4, 984-1001.

https://doi.org/10.1039/D5LP00379B

ChemRxiv preprint DOI: 10.26434/chemrxiv-2025-n1bqn

RSC Applied Polymers Emerging Investigators 2025

Promotional slide_D5LP00379B_Karayilan.jpg

[21] Thermoresponsive and Flow Behavior of Hyperbranched Polymers from ATRP Inimer

K. Raheja, A. Shorin, D. Gagnon, R. Lutz, B. Hasan, M. Singh, S. M. Parker, S. Morozova, M. Karayilan,* J. Polym. Sci., 2025, 63 (23), 5115-5130.

https://doi.org/10.1002/pol.20250830

ChemRxiv Preprint DOI: 10.26434/chemrxiv-2025-btj2g

[20] Dual-Degradable and Reprocessable Hyperbranched Polymers from Chain Transfer Agent-Lipoic Acid Conjugate

M. K. Debnath, N. Nupnar, Y. Yuan, E. R. Kone, V. O. Rodionov, M. J. A. Hore, M. Karayilan,* Macromolecules, 2025, 58, 18, 9930–9943

https://doi.org/10.1021/acs.macromol.5c01498

[19] Automated RAFT Polymerization using Batch, Increment, and Continuous Addition Modes to Enhance Properties of Fluorescent Polymers

S. Beilharz, J. M. Urueña, Z. Nett, M. W. Bates, L. Hughes, K. Raheja, M. Karayilan,* MRS Commun., 2025.

https://doi.org/10.1557/s43579-025-00803-z

ChemRxiv Preprint DOI: 10.26434/chemrxiv-2025-tp670

[18] Injectable Fluorescent Bottlebrush Polymers for Interventional Procedures and Biomedical Imaging

Y. Yuan, S. Beilharz, H. Everson, N. Nupnar, M. K. Debnath, D. Vinella, J. M. Urueña, F. Orge, M. J. A. Hore, D. Mathur, M. Karayilan,* Biomacromolecules, 2025, 26, 2, 1234–1250.

https://doi.org/10.1021/acs.biomac.4c01550

[17] Advances in Injectable Polymeric Biomaterials and Their Contemporary Medical Practices

S. Beilharz, M. K. Debnath, D. Vinella, A. J. Shoffstall, M. Karayilan,* ACS Appl. Bio Mater., 2024, 7, 12, 8076–8101.

https://doi.org/10.1021/acsabm.4c01001

[16] Summer Research Plan in Polymer Chemistry Laboratory for ACS Project SEED Program

S. Beilharz, M. Vermut-Young, K. Anderson, D. Vinella, A. Pahuja, Y. Yuan, K. Raheja, C. E. Crespo-Hernández, M. Karayilan,* J. Chem. Educ., 2024, 101, 3, 1120–1129. https://doi.org/10.1021/acs.jchemed.3c01175

[15] NMRium: Teaching Nuclear Magnetic Resonance Spectra Interpretation in an Online Platform

L. Patiny, H. Musallam, A. Bolaños, M. Zasso, J. Wist, M. Karayilan, E. Ziegler, J. C. Liermann, N. E. Schlörer, Beilstein J. Org. Chem., 2024, 20, 25-31.

https://doi.org/10.3762/bjoc.20.4

[14] Formation of Choline Salts and Dipolar Ions for CO2 Reactive Eutectic Solvents

R. Dikki, E. Cagli, D. Penley, M. Karayilan, B. Gurkan,* Chem. Commun., 2023, 59, 12027-12030.

https://doi.org/10.1039/D3CC03272H

Screen Shot 2023-11-21 at 10.28.56 AM.png

[13] Thermoresponsive Polymers with LCST Transition: Synthesis, Characterization, and Their Impact on Biomedical Frontiers

Y. Yuan, K. Raheja, N. B. Milbrandt, S. Beilharz, S. Tene, S. Oshabaheebwa, U. A. Gurkan, A. C. S. Samia, M. Karayilan,* RSC Appl. Polym., 2023, 1, 158-189.

https://doi.org/10.1039/D3LP00114H.

RSC Applied Polymers Blog - Hear from Authors

Prior to CWRU

[12] Reassessing Undergraduate Polymer Chemistry Laboratory Experiments for Virtual Learning Environments

M. Karayilan,* S. McDonald, A. Bahnick, K. Godwin, Y. M. Chan, M. L. Becker, J. Chem. Educ., 2022, 99, 5, 1877-1889.

From benchtop to desktop: Adapting chemistry laboratory experiments to virtual learning environments.

[11] Zooming in on Polymer Chemistry and Designing Synthesis of High Sulfur-Content Polymers for Virtual Undergraduate Laboratory Experiment

M. Karayilan,* J. Vakil, D. Fowler, M. L. Becker, C. T. Cox, J. Chem. Educ., 2021, 98, 6, 2062–2073.

[10] Polymeric Materials for Eye Surface and Intraocular Applications

M. Karayilan, L. Claimen, M. L. Becker, Biomacromolecules, 2021, 22, 2, 223–261.

[9] Increasing the rate of the hydrogen evolution reaction in neutral water with protic buffer electrolytes

K. E. Clary, M. Karayilan, K. C. McCleary-Petersen, H. Petersen, R. S. Glass, J. Pyun, and D. L. Lichtenberger, PNAS, 2020, 117 (52) 32947-32953.

[8] Influence of Processing Environment on the Surface Composition and Electronic Structure of Size-Quantized CdSe Quantum Dots

R. C. Shallcross, A. L. Graham, M. Karayilan, N. G. Pavlopoulous, J. Meise, J. Pyun, and N. R. Armstrong, J. Phys. Chem. C, 2020, 124, 39, 21305–21318

[7] Synthesis of Metallopolymers via Atom Transfer Radical Polymerization from a [2Fe‐2S] Metalloinitiator: Molecular Weight Effects on Electrocatalytic Hydrogen Production

M. Karayilan, K. C. McCleary‐Petersen, M. O. Hamilton, L. Fu, K. Matyjaszewski, R. S. Glass, D. L. Lichtenberger, and J. Pyun, Macromol. Rapid Commun. 2020, 41, 1900424

Special Issue: 100 Years of Macromolecular Chemistry

[6] Chalcogenide hybrid inorganic/organic polymer resins: Amine functional prepolymers from elemental sulfur

M. Karayilan, T.S. Kleine, K. J. Carothers, J. J. Griebel, K. M. Frederick, D. A. Loy, R. S. Glass, M. E. Mackay, K. Char, and J. Pyun, J. Polym. Sci. 2020, 58, 35-41.

[5] Water-soluble and air-stable [2Fe-2S]-metallopolymers: A new class of electrocatalysts for H2 production via water splitting

R. S. Glass, J. Pyun, D. L. Lichtenberger, W. P. Brezinski, M. Karayilan, K. E. Clary, and D. H. Evans, Phosphorus, Sulfur, and Silicon and the Related Elements, 2019, 194 (7), 701-706.

[4] Catalytic Metallopolymers from [2Fe‐2S] Clusters: Artificial Metalloenzymes for Hydrogen Production

M. Karayilan, W. P. Brezinski, K. E. Clary, D. L. Lichtenberger, R. S. Glass, J. Pyun, Angew. Chem. Int. Ed., 2019, 58, 7537.

[3] Nucleophilic Activation of Elemental Sulfur for Inverse Vulcanization and Dynamic Covalent Polymerizations

Y. Zhang, N.G. Pavlopoulos, T.S. Kleine, M. Karayilan, R.S. Glass, K. Char, and J. Pyun, J. Polym. Sci. Part A: Polym. Chem., 2019, 57, 7-12

[2] Macromolecular Engineering of the Outer Coordination Sphere of [2Fe-2S] Metallopolymers to Enhance Catalytic Activity for Hydrogen Production

W. P. Brezinski, M. Karayilan, K. E. Clary, K. C. McCleary-Petersen, L. Fu, K. Matyjaszewski, D. H. Evans, D. L. Lichtenberger, R. S. Glass, and J. Pyun, ACS Macro Letters, 2018, 7 (11), 1383-1387.

[1] [FeFe]‐Hydrogenase Mimetic Metallopolymers with Enhanced Catalytic Activity for Hydrogen Production in Water

W. P. Brezinski, M. Karayilan, K. E. Clary, S. Li, L. Fu, K. Matyjaszewski, D. H. Evans, R. S. Glass, D. L. Lichtenberger, J. Pyun, Angew. Chem. Int. Ed., 2018, 57, 11898.

Patents, Patent Applications, and Invention Disclosures

@ Case Western Reserve University

[7] Injectable fluorescent bottlebrush polymers for interventional procedures and biomedical imaging (2025)

Karayilan, M.; Mathur, D.; Orge, F.; Yuan L.; Beilharz, S. | 63/747,935

[6] Injectable Stimuli-Responsive Polymers (2024)

Karayilan, M.; Debnath, M. K.; Raheja, K.

@ Duke University

[5] Tri-arm star bottlebrush polymer with defined viscosity and optical properties for use in a novel intraocular lens (2022)

Becker, M. L.; Karayilan, M.; Clamen, L. | 63/344,186

https://patents.google.com/patent/US20250277078A1/en

[4] Biostable polymer brushes with defined viscosity and optical properties for use in a novel intraocular lens (2021)

Becker, M. L.; Karayilan, M.; Clamen, L. | 63/191,018 PCT/US2022/030255

https://patents.google.com/patent/US20240287232A1/en

@ The University of Arizona

[3] Electrocatalytic Systems for the Generation of Molecular Hydrogen from Aqueous Feedstocks

Pyun, J.; Glass, R. S.; Lichtenberger D. L.; Brezinski, W. P.; Clary, K. E.; Karayilan, M. | UA18-069

[2] Enhanced water electrolysis with protic co-catalysts (2019)

Lichtenberger, D. L.; Pyun, J.; Glass, R. S.; Brezinski, W. P.; Clary, K. E.; Karayilan, M.; | US62/597,242

https://patents.google.com/patent/US11846032B2/en

[1] Metallopolymers for catalytic generation of hydrogen (2019)

Pyun, J.; Glass, R. S.; Lichtenberger D. L.; Brezinski, W. P.; Clary, K. E.; Karayilan, M. | US16/466,571

https://patents.google.com/patent/US11649548B2/en

“I'm a great believer in luck, and I find the harder I work, the more I have of it " -T. Jefferson

Publications

Prior to CWRU

Patents, Patent Applications, and Invention Disclosures​

Patents, Patent Applications, and Invention Disclosures